Young adult mystery Death Spiral is working double duty: It introduces the Poisoned Pencil, the new YA mystery imprint of Poisoned Pen Press, and kicks off the Faith Flores Science Mysteries.

Death Spiral by Janie ChodoshDeath Spiral might be intended for teen readers, but this science thriller tackles some dark stuff. Sixteen-year-old Faith Flores wants to go to college and study science, but she has a lot to overcome. When her junkie mom dies, Faith doesn’t believe it was an overdose, and she begins a dangerous search for the truth that takes her from the drug houses of North Philadelphia to the labs of the pharmaceutical industry.

Author Janie Chodosh is a "scientist wannabe and a naturalist." Chodosh shares 10 fascinating tidbits on the science behind her debut:

Death Spiral: A Faith Flores Science Mystery is a genetics-based mystery. Check out this list of interesting genetics facts that inspired the story of Faith Flores and her quest to find the true cause of her mother’s death from a supposed heroin overdose.

1) The human genome consists of approximately 3 billion chemical base pairs and about 21,000 protein-coding genes. There are probably thousands more genes. Despite so many base pairs, any pair of humans is 99.9% identical in DNA.

2) Many genes play a role in addiction. For example, The A1 allele of the dopamine receptor gene DRD2 is more common in people addicted to alcohol or cocaine.

3) Although no mice were tested on to write this book, with the help of mouse studies, scientists have identified many genes that play roles in addiction. The reason mice are so helpful in studying addiction is because the reward pathway in our brains functions in much the same way in mice as it does in people. (If you want to know about mice and their addiction issues, read the subpoints; if rodent addiction is not of interest to you, move on to #4.)

a) Mice lacking the serotonin receptor gene Htr1b are more attracted to cocaine and alcohol.

b) Mice bred to lack the β2 subunit of nicotinic cholinergic receptors have a reduced reward response to cocaine.

c) Mice with low levels of neuropeptide Y drink more alcohol, whereas those with higher levels tend to abstain.

4) Gene therapy is a set of methods that uses genes to treat or prevent disease by inserting genes into a patient’s cells. There are three approaches to gene therapy: replacing a disease-causing gene with a healthy copy of the gene; inactivating a mutated gene; or introducing a new gene to help fight a disease.

5) When many people, including yours truly, think of patents, they think of things like curling irons and doodads that make cars work. In fact, the U.S. Patent and Trade Office has been issuing patents on genetic material since 1982. There are currently 3,000 to 5,000 patents on human genes in the United States.

6) However, (see #5) on June 13, 2013, the U.S. Supreme Court ruled that human genes could not be patented.

7) Opponents of genetic patents worry about the financial aspect of gene patenting. What about this: If just one company is allowed to patent a particular genetic test or treatment, they will have a monopoly for the term of the patent and can charge whatever they like for it, limiting access to people who cannot afford to pay. Or this: Without any competition from other researchers, the company who owns the patent wouldn't necessarily have to respond to consumer feedback.

8) Myriad Genetics filed several patents for BRCA1 and BRCA2, genes associated with breast and ovarian cancer. In March 2010, a U.S. District Court ruled that the company's patent claims were invalid because genetic material was, in fact, a product of nature.

9) The age of personal genomic medicine is here. Whereas it used to cost hundreds of thousands of dollars to get a genome sequenced, the cost has gone as low as $1,000 and will continue to get cheaper. However, getting the meaning out of the data might cost you a lot more. Plus, where are you going to keep that valuable information?

10) We can find now find out if we are carriers for thousands of different diseases with a genetic component—things like Alzheimer’s Disease, Schizophrenia and Huntington’s Disease. Now, the question is, do we want to know? And if you know, it might have an impact on your siblings and children.

 

Thanks, Janie! Readers, Death Spiral is out now.

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