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Although some medical statistics point out that one in 88 people has some form of autism, the diagnosis is still very little understood. Is it a psychological condition? Is it biological? Are children born autistic, or does their environment contribute to, and perhaps cause, their autism?

In this brilliant book that is part memoir and part scientific study, best-selling author Temple Grandin, one of the world’s most accomplished and well-known adults with autism, probes the causes of the condition, encouraging us to think differently about it and to embrace the strengths autism bestows.

When Grandin’s mother noticed her young daughter exhibiting symptoms that we now label autistic—destructive behavior, inability to speak, sensitivity to physical contact—she took her to a neurologist rather than to a psychologist. The doctor diagnosed the young girl with brain damage, and Grandin’s mother carried out a program of intense individual therapy, engaging with the young Grandin one-on-one, a therapy now commonly practiced with autistic individuals today. Grandin points out that, given the rapidly changing views about autism and its causes, a mere decade later a doctor might have told her mother that the problem was all in the child’s mind.

Drawing on extensive and in-depth examinations of the science of the brain and contemporary genetics, Grandin challenges the idea that autism is “all in the mind” and merely a psychological condition that can be accurately diagnosed for every individual case. Indeed, there is no single cause or single symptom for autism. The search for causes for autism “involves the observation of neurological and genetic evidence and looking for each symptom along the whole spectrum.”

She points out that every case is widely different and no two people with autistic tendencies can be treated the same way. The spectrum of autistic individuals includes what she calls “three-kinds-of-minds”: pattern thinkers who are able to see and understand the forms behind the words but who have difficulty with reading and writing; picture thinkers who excel at understanding shapes and learn from hand-on activities; word-fact thinkers who perform poorly at drawing but interact with the world through their stellar writing skills. Prepared with this knowledge, schools and therapists should never ask an autistic individual to learn in a way that he or she can’t understand.

In The Autistic Brain, Grandin revolutionizes our way of thinking about autism, urging us not to fall into labeling or believe that we can only ever respond in one way to an autistic individual.

Although some medical statistics point out that one in 88 people has some form of autism, the diagnosis is still very little understood. Is it a psychological condition? Is it biological? Are children born autistic, or does their environment contribute to, and perhaps cause, their…

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“Stereo Sue” sounds like the handle of a fast-talking disc jockey, but Susan Barry, author of Fixing My Gaze: A Scientist’s Journey Into Seeing in Three Dimensions, is actually a neuroscience professor. On top of that, she is probably her own most famous experiment. Oliver Sacks, author of The Man Who Mistook His Wife For a Hat, wrote an article called “Stereo Sue” for the New Yorker, and also introduces this book.

Barry was born with crossed eyes, and the vision centers in her brain compensated by allowing her to see without double vision. Her condition—seeing, essentially, in two dimensions—is called stereoblindness. It was not until Barry was in her late 40s that she undertook the developmental optometry that taught her, through perseverance, to see in three dimensions. In Fixing My Gaze, she chronicles this process with plenty of illustrations and scientific terms, explaining each phrase for her lay readers. A complete glossary also helps readers understand some of the necessary language.

Filled with clear diagrams that illustrate the difference between how the stereoblind and normally sighted people see, Fixing My Gaze introduces readers to a rare but interesting disability. It is also a testament both to human physiology and spirit that permits someone to live with—and then change—a uniquely altered view of the world. As Barry writes, “What a magnificent feeling it is to take control of your own vision and solve your own problems.”

My own seven-year-old son is currently working with a developmental optometrist to help him with his “tracking.” He does not naturally see from left to right, or top to bottom. Instead, his eyes jump all over the page. His reading tutor recommended vision therapy, and we hope it will help him as it helped Barry. This book opens up the possibility that people can change their physical limitations, and that it is never to late to try.

Eliza McGraw writes from Washington, D.C.

“Stereo Sue” sounds like the handle of a fast-talking disc jockey, but Susan Barry, author of Fixing My Gaze: A Scientist’s Journey Into Seeing in Three Dimensions, is actually a neuroscience professor. On top of that, she is probably her own most famous experiment. Oliver…

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With his close-cropped hair and three-day stubble, Nathan Wolfe looks every bit the warrior on the front line of a crucial battle. But Wolfe isn’t fighting a conventional war against other human beings. He is fighting to save the human race, seeking to discover and neutralize deadly viruses before they blossom into an epidemic. Wolfe, a Stanford biologist, is director of Global Viral Forecasting, an organization that identifies infectious diseases before they become full-blown pandemics. He is also the author of an eye-opening book, The Viral Storm, an account of the struggle to control the spread of lethal viruses.

Wolfe’s book is startling in its revelations of just how vulnerable we are to infectious outbreaks. He attributes our susceptibility to viruses to our early ancestors who chose to consume bacteria-laden animal flesh over plant life. More recently, once-contained diseases were able to spread from the moment Columbus and other explorers brought animals, insects and rodents from the Old World to the New, and vice versa. Modern air travel and the global trade of livestock and crops have accelerated the spread of viruses today.

What makes The Viral Storm more alarming is information on just how resourceful and adaptable disease-carrying microbes can be. They must find and attach themselves to a host—animal or human—to survive, then figure out a way to spread, most often through coughing, sneezing, skin-to-skin contact or blood transmission. And these microbes are resilient, constantly mutating to survive attacks from antibiotics and other enemies.

Fortunately, Wolfe is among a number of scientists who travel the globe trying to identify new viruses and prevent their spread. He shares his experiences and discoveries in the jungles of Africa and the South American rainforests as he hunts for the origins of new deadly diseases, and identifies new technologies being employed to stop future outbreaks. The Viral Storm will scare you, educate you and leave you with a sense of hope that science and public policy can improve world health and someday eliminate epidemics altogether.

With his close-cropped hair and three-day stubble, Nathan Wolfe looks every bit the warrior on the front line of a crucial battle. But Wolfe isn’t fighting a conventional war against other human beings. He is fighting to save the human race, seeking to discover and…

Trim, athletic and recently retired, Dave Simon enjoyed playing tennis and was working hard to take his game to a new level. During a match, as he lunged to return a ball, he collapsed onto the court; though he tried to get up, he could not move his right arm or leg, and he couldn't speak to answer his tennis partner's questions. Just as he was struggling to find his voice, the door to the examining room snapped open and his doctor's voice greeted him, shaking Simon out of his daydream of being stricken by a stroke. When the doctor asked Simon about his decision to begin drug therapy for atrial fibrillation, the patient—vacillating between his terror of a stroke and the adverse side effects of such drugs on a good friend—simply replied that he had not yet decided to commence treatment.

In Your Medical Mind, a compelling study of the ways we make our decisions about personal health care, Dr. Jerome Groopman and Dr. Pamela Hartzband show that Simon is hardly alone in his ambivalence in seeking a course of treatment whose benefits must be balanced against its drawbacks. Drawing on interviews with a range of patients who have had to make decisions regarding cancer, heart disease and the end of life, the two doctors provide a useful chart of the approaches that individuals take to medical decision-making.

Some patients are maximalists who believe that they are making the best medical choices for themselves by embracing the full range of recommendations—tests, drug therapies, surgery—their physicians make in order to preserve health. Others are minimalists who often avoid treatment, try to use the fewest medications and the lowest dosages of those drugs, and select conservative procedures. Then there are believers who approach each situation with the optimism that there will be a successful solution; doubters approach treatment with profound skepticism and are often unwilling to take risks when the adverse consequences might outweigh the benefits of a procedure or therapy. While believers are most often maximalists and doubters most often minimalists, the authors point out that there are always exceptions to this characterization. Some patients have an orientation toward naturalism and seek out natural remedies or homeopathic treatments and even then partake of those quite sparingly.

With the advent of medical sites and patient blogs on the Internet, television and radio commercials about the promising benefits and the chilling side effects of drugs, conflicting advice from personal doctors and specialists, and the promise of natural remedies and therapies, patients now have more difficulty than ever before in making decisions about how to proceed after a difficult diagnosis or which procedures or treatments might be best for them in a certain situation. Groopman and Hartzband masterfully help us all navigate these choppy medical waters.

Trim, athletic and recently retired, Dave Simon enjoyed playing tennis and was working hard to take his game to a new level. During a match, as he lunged to return a ball, he collapsed onto the court; though he tried to get up, he could…

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In journalist Julie Salamon’s Hospital: Man, Woman, Birth, Death, Infinity, Plus Red Tape, Bad Behavior, Money, God, and Diversity on Steroids, you won’t find interns and residents incessantly worrying over their love lives while treating patients suffering from horrific accidents and outrageously unbelievable situations. Instead, you’ll find real-life, day-to-day drama, big and small, with a huge staff (6,210) of doctors, nurses, administrators and others playing their parts.

The hospital in question is Maimonides Medical Center in Borough Park, Brooklyn, a major hospital that for many years served a neighborhood of Orthodox and Hasidic Jews. More recently, however, the area has become increasingly multicultural, with no less than 67 languages spoken by the hospital’s staff and patients. This proved irresistible to Salamon (The Devil’s Candy, The Christmas Tree), who spent a year at Maimonides, talking to everyone, seemingly, who passed through. Her thorough and thoughtful research pays off in the broad, yet detailed strokes she paints of the complex relationships, financial constraints, and medical mysteries and miracles inside.

Salamon guides us through a broad cast of characters in an organized way, beginning with a helpful list of them all. She paints well-rounded portraits of everyone, including, for example, Mr. Zen, an illegal immigrant with cancer who doesn’t want to leave the hospital because he has nowhere else to go. We meet a first-year, surf-loving resident named David, a Nebraskan full of wonder, and, of course, exhaustion. And there is hospital president and CEO Pam Brier, who just before taking over the reins was in a car accident that almost killed her and her husband. Her recovery and drive alone would be enough material for a book.

Hospital starts with the top executives and extends out into Borough Park, showing how the Maimonides staff strives to reach out to the community. Salamon knows how to weave a story well, and here she weaves many stories with drama and grace.

Alice Cary writes from Groton, Massachusetts.

In journalist Julie Salamon's Hospital: Man, Woman, Birth, Death, Infinity, Plus Red Tape, Bad Behavior, Money, God, and Diversity on Steroids, you won't find interns and residents incessantly worrying over their love lives while treating patients suffering from horrific accidents and outrageously unbelievable situations. Instead,…
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When Sigmund Freud and William Halsted began experimenting on themselves with cocaine in the 1880s, “addiction” was not yet a medical diagnosis. Yes, people knew about the ravages of “Demon Alcohol” and saw a downside to widely prescribed opiates. But an understanding of the commonalities of something known as “addiction” was not yet documented. Cocaine, a newly popular ingredient in elixirs like Coca-Cola, was promoted as having astonishing medical properties.

In An Anatomy of Addiction, University of Michigan medical historian Howard Markel explores the impact of cocaine use on two of the period’s most prominent medical pioneers. It’s a story that has never before been told in such depth or in so readable a form. Markel, the author of the award-winning Quarantine! and When Germs Travel, has an unrivaled knack for research and narrative. So he is able to paint compelling and nuanced portraits of Freud and Halsted, the foremost surgeon of his day, and to convey the excitement and physical and psychological risk of an era of remarkable medical advances.

Halsted began exploring cocaine’s potential as anesthesia in major surgery by injecting the drug under his skin. A leading exponent of now-discredited forms of radical surgery and a highly influential leader in the adoption of sterile operating procedures, Halsted became addicted. After a number of hospitalizations he was rescued by a colleague and became leading professor at John Hopkins Medical School, which soon became the most influential medical institution in the world. Halsted remained an addict all his life, though a high-performing one, and Markel provocatively suggests that cocaine may have “given rise to the greatest school in surgery this country has ever seen,” though it also grievously stunted Halsted’s personal life.

Sigmund Freud began his self-experimentations with the drug in the dual hope of curing a friend of morphine dependency and writing a groundbreaking research article that would launch his career (and provide him the financial stability he needed to marry his long-enduring fiancée). The influence of cocaine on his early career is more difficult to precisely document, but here, too, based on his research, Markel is wonderfully suggestive.

Yet Freud managed to overcome his drug dependency. How? Markel says that Freud’s driving intellectual ambition demanded the predictable routines and accountability that “served as the ideal therapeutic program.” Soon thereafter, Freud entered the period “when he became one of the greatest intellectuals of his generation and provided a modern language for understanding the unconscious mind.”

“One only wishes,” Markel writes, “that [Freud had] had similar fortitude to put down his addictive and cancer-producing cigars, which, beginning in 1923 . . . robbed him of an intact, functioning mouth and forced him to undergo multiple painful surgeries and wear ill-fitting prostheses.” That addiction finally cost Freud his life.

When Sigmund Freud and William Halsted began experimenting on themselves with cocaine in the 1880s, “addiction” was not yet a medical diagnosis. Yes, people knew about the ravages of “Demon Alcohol” and saw a downside to widely prescribed opiates. But an understanding of the commonalities…

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One sad lesson to be learned from Side Effects: when you’re considering whether to take a new medication, don’t assume anything. Don’t assume the medical researchers didn’t manipulate their findings. Or that the pharmaceutical company released all its data. Or that the Food and Drug Administration made sure the medicine is safe. Alison Bass, a former Boston Globe reporter who specializes in medical issues, delivers that tough truth through the tale of Paxil, a popular antidepressant widely prescribed for children and adolescents – before it became clear that Paxil and similar drugs increase suicidal thoughts among some pediatric patients. The FDA now requires warning labels on those medications, but that step came only after a struggle between “Big Pharma” and patient advocates.

Bass focuses on a precedent-setting legal case brought by the New York State Attorney General’s Office against GlaxoSmithKline, accusing the company of hiding negative findings about Paxil. She humanizes the somewhat complex story through the experiences of a handful of dogged whistleblowers: a legally blind prosecutor who noticed the data in a key Paxil study didn’t match its positive conclusion; a health care administrator who stumbled over what Bass says were research misdeeds at Brown University; and a psychiatrist who first reported in 1990 that some patients became suicidal after they were prescribed Prozac.

The whistleblowers’ persistence has paid off to some extent. The FDA has become somewhat more vigilant, and medical journals are more careful about the research they publish. But Bass shows that ethically dubious financial ties between pharmaceutical companies and the medical research community continue unabated. Her prime example is a senior psychiatrist at Brown implicated in questionable practices in the Paxil case and others. He refused to speak to Bass, and remains in good standing at Brown.

Anne Bartlett is a journalist in Washington, D.C.

One sad lesson to be learned from Side Effects: when you're considering whether to take a new medication, don't assume anything. Don't assume the medical researchers didn't manipulate their findings. Or that the pharmaceutical company released all its data. Or that the Food and Drug…
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The many lurid and confessional hospital dramas now on television can make it seem like nothing new or particularly revelatory can be said about the inner lives of healthcare professionals. Challenging this assumption is an unusual new memoir—by turns both brutal and lyrical—by a longtime itinerant nurse who first discovered her talent for lucid introspection as a published poet.

Mary Jane Nealon’s Beautiful Unbroken is a parable about the elastic limits of our ability to help others. It pivots around one specific tragedy: the death of Nealon’s younger brother Johnny from cancer in the 1970s. Freshly graduated from nursing school but emotionally unable to stay beside her family during Johnny’s swift decline, she subsequently spent her 20s and 30s practicing compassion at strangers’ bedsides to exorcise feelings of guilt.

Despite this psychic burden, Nealon comes across as an earthy, engaging character. This 20-something fledgling nurse loved reggae and Latin dancing and was not averse to a little recreational cannabis or regular bouts of unmarried sex. Comforted by the fact that a saint-like desire to save lives and ease suffering could be fulfilled by someone far from saint-like, she identified more with her dashing cop father than her demure mother.

She wrote and performed poetry while serving in Manhattan cancer wings and kept writing whenever she was posted to cities where poetry workshops were available. The best sections of this autobiography show the results of these apprenticeships: unflinching revelations couched in beautiful allusions and startling metaphors. She tells us her brother’s laugh was “like smooth hay blowing this way and that way around the house.” She describes her acceptance to a year-long writing fellowship as a needed break from fighting the AIDS epidemic: “I felt as if I had finally come out of the dressing room wearing my own skin, and in the mirror I saw the possibilities of my own shape.”

Nevertheless, this is not an easy book to read. If you are squeamish, be warned that Nealon makes us watch while she attends the severely injured or dying. She skillfully evokes the messy fluids and despair of home hospice work and AIDS units. Yet her vivid recollections, so cool and succinct, evoke empathy rather than horror. How many times have we passed a nurse or doctor in hospitals and wondered how they survive daily exposure to so much pain? Beautiful Unbroken doesn’t completely answer that question, but it makes us understand through Nealon’s own triumphs and failures exactly why the question must be asked.

 

The many lurid and confessional hospital dramas now on television can make it seem like nothing new or particularly revelatory can be said about the inner lives of healthcare professionals. Challenging this assumption is an unusual new memoir—by turns both brutal and lyrical—by a longtime…

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Atul Gawande writes for The New Yorker, but by trade he‘s a surgeon; after a particularly harrowing operation in which the patient nearly died, he took a hard look at what had gone wrong and he found that a simple error had nearly doomed his patient. Not long after, he happened upon an anecdote that piqued his interest—an account of an Austrian community hospital where a girl had been brought back from apparent brain death due to drowning. Intrigued, he began searching the literature for a confirmation of what had occurred in Austria, and he found it in a Johns Hopkins study detailing a reduction in infections after surgery. They had one factor in common, and that was the use of a checklist.

The Checklist Manifesto is Gawande’s account of this “aha!” moment, and his search—under the auspices of the World Health Organization—to find out if something as simple as a checklist could improve patient survival rates. The quest led him in many different directions, one of which was the obvious idea of trying it out in real-life situations. As he recounts, this was not as easy as it might seem, because surgeons as a rule are confident and headstrong and don’t take kindly to being second-guessed by a sheet of paper. It also led him to the construction industry and the complex process of building a skyscraper. To ensure that tasks get done correctly (and to keep the thing from collapsing), construction engineers use—you guessed it—a checklist. Finally, Gawande gained some priceless insight from the aviation industry.

Unless you avoid newspapers and television, you’ve probably heard of Captain “Sully” Sullenberger, the pilot of US Airways Flight 1549. After taking off from New York City’s LaGuardia Airport on January 15, 2009, the plane struck a flock of geese, unbelievably losing both engines in the process. While he was justly heralded for gliding the airliner to a safe landing in the Hudson, Sullenberger resisted efforts by the press to make him a hero, insisting that it was a team effort. Gawande points out that today’s modern airliner is so incredibly complex that no one person, or even a team of people, can operate one safely on their own; the crew of Flight 1459 relied on a simple tool during their forced landing. That tool is one that has been used by pilots everywhere almost since the dawn of aviation—the checklist.

Atul Gawande’s determined effort to see his theory through is at the heart of The Checklist Manifesto, and its implications are widespread; he shows us a simple tool for complex problems that can be applied to business, government and just about any situation where unanticipated complications can lead to disaster. It remains to be seen whether this surgical Cassandra’s solution will be heeded.

James Neal Webb works for the Vanderbilt University Library.

Atul Gawande writes for The New Yorker, but by trade he‘s a surgeon; after a particularly harrowing operation in which the patient nearly died, he took a hard look at what had gone wrong and he found that a simple error had nearly doomed his…

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If you ask someone born after World War II about sulfa drugs, you’ll likely get a blank stare. Ask the same question of someone born before the war, however, and it’s a different story. That’s because while the reign of sulfanilamide and its numerous variants was brief a mere decade before other, more effective drugs emerged it changed the world in a way no one then alive will ever forget. As recounted in Thomas Hager’s first book, The Demon Under the Microscope: From Battlefield Hospitals to Nazi Labs, One Doctor’s Heroic Search for the World’s First Miracle Drug, the introduction of sulfa drugs meant that for the first time in history a person with a bacterial infection could expect not just hope, but reasonably expect to live. Who was responsible for this miracle cure? As with most great scientific and technological advances, it is difficult to credit a single person. So many doctors, chemists and industrialists contributed to the discovery that even a comprehensive history like Hager’s can’t give every one his or her due. But one name does stand out Gerhard Domagk, a German doctor and medical researcher who watched too many soldiers die of gangrenous infection in World War I. His dedication to finding a cure, coupled with the work of talented chemists and the financing of one the world’s largest chemical companies (Bayer), resulted in the earth-shaking breakthrough at Christmas 1932. For this great humanitarian work, Domagk was awarded the 1939 Nobel Prize in medicine, which the Nazis prevented him from accepting. Soon, the second great war in a generation swept Europe but this time, wounded soldiers and civilians knew they had a fighting chance.

The tale of sulfa drugs, credited with saving hundreds of thousands of lives, is told by Hager in a thorough, yet highly readable style that grips the reader from the first paragraph. It is a story of dedication, luck, tragedy and triumph that’s still relevant today. Chris Scott writes from Nashville.

If you ask someone born after World War II about sulfa drugs, you'll likely get a blank stare. Ask the same question of someone born before the war, however, and it's a different story. That's because while the reign of sulfanilamide and its numerous variants…
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The thing about The Thing About Life Is That One Day You'll Be Dead is that it sounds like a very depressing book. Instead, however, it's an involving read, an unusual blend of science, culture and family history.

In his ninth book, David Shields uses sources from around the world and from his own life to consider what it means to be alive and human. This is a far-reaching quest: Lyndon Johnson, Arthur Schopenhauer, Shields' cat Zoomer, Wallace Shawn, Kurt Cobain, Elizabeth Barrett Browning and Neil Young are all here, offering momentary points of illumination for Shields' often obscure search. Shields frames his unruly investigation in terms of his relationship with his 97-year-old father, and frames his book in terms of the human life cycle. At 51 years old, the author is preoccupied with mortality and encroaching death, while his aged father, fascinated by survival, also typifies it.

The author begins, naturally enough, with a chapter about infancy, and the chapters march along chronologically with discussions of adolescence, middle age and old age. Within several sections, there are chapters called "Decline and Fall," an echoing reminder of how different stages of life prefigure or recall others. Just as a 40-year-old realizes that his 30s, his most creative years, are behind him, a 65-year-old has to grapple with the loss of one-tenth of his brain cells. Each stage of life comes complete with its own downfall.

This is not necessarily an uplifting book, simply because its author's questioning of and sadness at the relentless nature of aging are too prescient to allow anyone to feel entirely carefree while reading it. But the book is not without hope, and Shields' constant probing is no less a means of survival than his father's tenacity. "He's strong and he's weak and I love him and I hate him and I want him to live forever and I want him to die tomorrow," Shields writes of his father. What, really, could sound more alive?

Eliza McGraw is a writer living in Washington, D.C.

The thing about The Thing About Life Is That One Day You'll Be Dead is that it sounds like a very depressing book. Instead, however, it's an involving read, an unusual blend of science, culture and family history.

In his ninth book, David Shields uses sources…

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Even today, there are conflicting estimates of how many deaths the great influenza pandemic of 1918 caused worldwide. In 1927, an American Medical Association study set the total at a conservative 21 million. Some say it was closer to 100 million. In the U.S. alone, where the disease is generally believed to have originated, approximately 675,000 citizens died.

This natural horror coincided with the last months of carnage of World War I, but as John M. Barry points out in The Great Influenza: The Epic Story of the Deadliest Plague in History, the disease was even more devastating than the battles. “In the American military alone,” the author reports, “influenza-related deaths totaled just over the number of Americans killed in combat in Vietnam [47,420]. One in every sixty-seven soldiers in the army died of influenza and its complications, nearly all of them in a ten-week period beginning in mid-September [1918].” Unlike pneumonia, which tended to kill infants, the old and the weak, this virulent strain seemed to target those who were young, strong and in the prime of their lives.

Barry, whose other books include Rising Tide: The Great Mississippi Flood of 1927, tells three separate but intertwined stories here. The first traces the history of American medicine from its primitive beginning to the start of the war; the second chronicles the spreading tentacles of the pandemic; and the third follows the medical community’s efforts to analyze and treat the disease and search for a cure.

Throughout his account, Barry criticizes President Woodrow Wilson and his administration for creating an unquestioning, suppressive pro-war climate that kept the public from recognizing and reacting sensibly to the disease. Time and again, medical precautions were ignored and vital news withheld for fear of damaging the war effort. Barry’s heroes are such valiant and foresighted doctors as William Welch, Simon Flexner and William Gorgas, who were rigorous in their attempts to cap the outbreak.

Believed to have originated in Haskell County, Kansas, in early 1918, the influenza spread across the country in two waves. The first one, in spring, was relatively mild. The second one was a rolling slaughterhouse. That fall, in the Camp Devens army encampment near Boston, deaths from the flu rose to an average of nearly 100 a day. Doctors and nurses began dying too. In Philadelphia, one of the cities hardest hit, the daily death toll soared briefly to around 800. There were neither enough coffins nor enough gravediggers to handle the onslaught. Entire families became sick and often had to wait for days for their dead to be taken away. Still, a cowed and “patriotic” press ignored or played down the city’s plight.

While medical and public health advances were made as it raged on, the plague essentially burned itself out, subsiding in America almost as quickly as it arose. Barry’s book is afflicted with a textbookish excess of detail at least for the general reader but it serves as a clear warning that governments must be open with their people and generous in their application of resources if they are to contain such present menaces as AIDS and SARS and slow the progress of epidemics yet to come.

Even today, there are conflicting estimates of how many deaths the great influenza pandemic of 1918 caused worldwide. In 1927, an American Medical Association study set the total at a conservative 21 million. Some say it was closer to 100 million. In the U.S. alone,…
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In 1980, the possibilities of artificial insemination inspired a strange experiment, mixed with elitism, an overdose of eugenics, a smattering of racism and the barest dollop of science. In The Genius Factory: The Curious History of the Nobel Prize Sperm Bank, David Plotz reveals an idea straight from a science fiction novel: to collect the sperm of the world’s leading scientific minds and create a generation of genius babies. The Genius Factory offers a fascinating glimpse into this very real, almost comically bizarre effort by a California millionaire to improve the American gene pool. Beyond simply examining the shaky science and equally shaky philosophy behind it all, Plotz explores the human impact, highlighted by interactions with a few of the donor fathers (none of whom were Nobel winners) and their offspring. Their stories range from the worst cases, where the impact on the child and adults was virtually unconsidered, to the best, where child, parents and donor found an unexpected bonus: not genius, but love. Howard Shirley is a son and a father.

In 1980, the possibilities of artificial insemination inspired a strange experiment, mixed with elitism, an overdose of eugenics, a smattering of racism and the barest dollop of science. In The Genius Factory: The Curious History of the Nobel Prize Sperm Bank, David Plotz reveals an…

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